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Mikki Kollisch

Research Scientist

Associate Professor Pediatric Surgery

Curriculum Vitae

Biosketch

Personal Statement

Mikki is an Associate Professor of Pediatric Surgery at Arkansas Children's Hospital. She completed a research fellowship in the Critical Care Research Laboratory at SUNY Upstate Medical University. Her research focus has been on understanding protective mechanical ventilation strategies and modifying trauma-associated morbidity and mortality.
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“Leap, and the net will appear." - John Burroughs

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Selected Articles

1.      Kollisch-Singule M, Emr B, Smith B, Roy SK, Jain SV, Satalin J, Snyder K, Andrews PL, Habashi NM, Bates JHT, Marx W, Nieman GF, Gatto LA. Mechanical breath profile of APRV minimizes micro-strain in acute lung injury. JAMA Surg. 2014;13:59.

 

2.      Kollisch-Singule M, Emr B, Bradford S, Ruiz C, Roy SK, Meng Q, Jain SV, Satalin J, Snyder K, Ghosh A, Marx W, Andrews PL, Habashi NM, Nieman GF, Gatto LA. Airway pressure release ventilation (APRV) reduced conducting airway micro-Strain in lung injury. J Am Coll Surg. 2014;219:968-976.

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3.      Emr B, Roy SK, Kollisch-Singule M, Gatto LA, Barravecchia M, Lin X, Young JL, Wang G, Liu J, Satalin J, Snyder K, Nieman GF, Dean DA. Electroporation Mediated Gene Delivery of Na+,K+-ATPase and ENaC Subunits to the Lung Attenuates Acute Respiratory Distress Syndrome in a Two-Hit Porcine Model. Shock. 2014;43:16-23.

 

4.      Smith BJ, Lundblad LKA, Kollisch-Singule M, Satalin J, Nieman GF, Habashi NM, Bates JHT. Predicting the response of the injured lung to the mechanical breath profile. J Apply Physiol. 2015;118:932.

 

5.      Andrews PL, Sadowitz B, Kollisch-Singule M, Satalin J, Roy SK, Snyder K, Gatto LA, Nieman GF, Habashi NM. Alveolar instability (atelectrauma) is not identified by arterial oxygenation predisposing the development of an occult ventilator-induced lung injury. Intensive Care Med Exp. 2015;3:16.

 

6.      Kollisch-Singule M, Jain SV, Andrews PL, Smith BJ, Hamlington-Smith KL, Roy SK, DiStefano D, Nuss E, Satalin J, Meng Q, Marx W, Bates JHT, Gatto LA, Nieman GF, Habashi NM. Effect of airwary pressure release ventilation on dynamic alveolar heterogeneity. JAMA Surg. 2015;3:35.

 

7.      Kollisch-Singule M, Emr B, Jain SV, Andrews PL, Satalin J, Liu J, Porcellio E, Kenyon V, Wang G, Marx W, Gatto LA, Nieman GF, Habashi NM. The Effects of Airway Pressure Release Ventilation on Respiratory Mechanics in an Extrapulmonary ARDS Model. Intensive Care Med Exp. 2015;3:35.

 

8.      Sadowitz B, Jain SV, Kollisch-Singule M, Satalin J, Andrews PL, Habashi NM, Gatto LA, Nieman GF. Preemptive Mechanical Ventilation Can Block Progressive Acute Lung Injury. World J Resp Crit Care Med. 2016;4:74.

 

9.      Jain SV, Kollisch-Singule M, Sadowitz B, Dombert L, Satalin J, Andrews PL, Gatto LA, Nieman GF, Habashi NM. The 30-year evolution of airway pressure release ventilation (APRV). Intensive Care Med Exp. 2016;4:11.

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10.      Kollisch-Singule M, Sadowitz B, Meng Q, Costanza MJ, Amankwah K. “Sustained Elevation in Monocyte Levels in Diabetic Patients after Infra-Inguinal Revascularization.” J Vasc Endovasc Surg. 2016;1:6.

 

11.      Kollisch-Singule M, Jain SV, Satalin J, Andrews PL, Searles Q, Liu Z, Zhou Y, Wang G, Meier AH, Gatto LA, Nieman GF, Habashi NM. Limiting ventilator associated lung injury in a pre-term porcine neonatal model. J Ped Surg. 2017;52:50-55.

 

12.      Jain SV, Kollisch-Singule M, Satalin J, Searles Q, Dombert L, Abdel-Razek O, Yepuri N, Leonard A, Gruessner A, Andrews PL, Gazal F, Meng Q, Wang G, Gatto LA, Habashi NM, Nieman GF. The role of high airway pressure and dynamic strain on ventilator-induced lung injury in a heterogeneous acute lung injury model. Intensive Care Med Exp. 2017;5.

 

13.      Nieman GF, Satalin J, Kollisch-Singule M, Andrews PL, Aiash H, Habashi NM, Gatto LA. Physiology in Medicine: Understanding dynamic alveolar physiology to minimize ventilator-induced lung injury. J Appl Physiol. 2017;122:1516-1522.

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14.      Costantino A, Hyatt C, Kollisch-Singule M, Jacques B, Roth BJ, Pertsov A. “Determining the Light Scattering and Absorption Parameters from Forward Directed Flux Measurements in Cardiac Tissue.” J of Biomed Optics. 2017;22:7.​

 

15.      Kollisch-Singule M, Jain SV, Andrews PL, Satalin J, Gatto LA, Villar J, De Backer D, Gattinoni L, Nieman GF, Habashi NM. Looking beyond macroventilatory parameters and rethinking ventilator-induced lung injury. J Appl Physiol. 2018;124:1220.

 

16.      Hasan D, Satalin J, van der Zee P, Kollisch-Singule M, Blankman P, Shono A, Somhorst P, den Uil C, Meeder H, Kotani T, Nieman GF. Excessive extracellular ATP desensitizes P2Y2 and P2X4 STP receptors provoking surfactant impairment ending in ventilation-induced lung injury. Int J Mol Sci. 2018;19:e1185.

 

17.      Kollisch-Singule M, Jain SV, Andrews PL, Satalin J, Gatto LA, Villar J, De Backer D, Gattinoni L, Nieman GF, Habashi NM. Last Word on Veiwpoint: Looking beyond macroventilatory parameters and rethinking ventilator-induced lung injury. J Appl Physiol. 2018;124:1220.

 

18.      Nieman GF, Andrews PL, Satalin J, Wilcox K, Kollisch-Singule M, Madden M, Aiash H, Blair SJ, Gatto LA, Habashi NM. Acute lung injury: How to stabilize a broken lung. Crit Care. 2018;22:136.

 

19.      Roy SK, Meng Q, Sadowitz B, Kollisch-Singule M, Yepuri N, Satalin J, Gatto LA, Nieman GF, Cooney RN, Clark D. Enteral administration of bacteria fermented formula in newborn piglets: A high fidelity model of necrotizing entercolitis (NEC) PLoS One. 2018;13:136.

 

20.      Nieman GF, Satalin J, Andrews PL, Wilcox K, Aiash H, Baker SJ, Kollisch-Singule M, Madden M, Gatto LA, Habashi NM. Preemptive mechanical ventilation based on dynamic physiology in the alveolar micro-environment: Novel considerations of time-dependent properties of the respiratory system. J Tr Acute Care Surg. 2018;85:1081.

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21.      Nieman GF, Satalin J, Kollisch-Singule M, Andrews PL, Aiash H, Habashi NM, Gatto LA. Reply to Drs. Monjezi and Jamaati: Dynamic alveolar mechanics are more than a soap bubble on a capillary tube. J Appl Physiol. 2018;125:525.

 

22.      Kollisch-Singule M, Andrews PL, Satalin J, Gatto LA, Nieman GF, Habashi NM. The time-controlled adaptive ventilation (TCAV) Protocol: Mechanistic approach to reducing VILI. European Resp Review. 2019:28:152. 

 

23.      Nieman GF, Al-Khalisy H, Kollisch-Singule M, Satalin J, Blair SJ, Trikha G, Andrews PL, Madden M, Gatto LA, Habashi NM. A physiologically informed strategy to effectively open, stabilize, and protect the acutely injured lung. Front Physiol. 2020;11:227.

 

24.      Kollisch-Singule M, Satalin J, Baker SJ, Andrews PL, Gatto LA, Nieman GF, Habashi NM. Mechanical Ventilation Lessons Learned from Alveolar Micromechanics. Front Physiol. 2020;11:233.

 

25.      Nieman GF, Gatto LA, Andrews PL, Satalin J, Camporata L, Daxon B, Blair SJ, Al-khalisy H, Madden M, Kollisch-Singule M, Aiash H, Habashi NM. Prevention and Treatment of Acute Lung Injury with Time-Controlled Adaptive Ventilation: Physiologically Informed Modification of Airway Pressure Release Ventilation. Ann Int Care. 2020;10:3.

 

26.      Kollisch-Singule M, Ramcharran H, Satalin J, Blair S, Andrews PL, Habashi NM, Nieman GF, Bougatef A. “Mechanical Ventilation in Pediatric and Neonatal Patients.” Frontiers in Physiology. Mar 2022. [PMID: 35369685]

 

27.      Habashi NM, Andrews PL, Kollisch-Singule M, Nieman G. “A Ventilator Cannot Set Itself nor can it be Solely Responsible for Outcomes.” Crit Care Med. Apr 2022. 50(4):695-9. [PMID: 35311779]

 

28.      Herrmann J, Kollisch-Singule M, Satalin J, Nieman GF, Kaczka DW. “Assessment of Heterogeneity in Lung Structure and Function During Mechanical Ventilation: A Review of Methodologies.” J of Med Diagn. Apr 2022. [PMID: 35832339]

 

29.      Meng Q, Wang X, Guo D, Shi C, Gu R, Ma J, Nieman GF, Kollisch-Singule M, Luo J, Cooney RC. “Nano-chemically modified tetracycline-3 (nCMT-3) attenuates acute lung injury via blocking sTREM-1 release and NLRP3 inflammasome activation.” Shock. May 2022. 57(5):749-58. [PMID: 35583915]

 

30.      Nieman GF, Kollisch-Singule M, Ramcharran H, Satalin J, Blair S, Gatto LA, Andrews PL, Ghosh A, Kaczka DW, Bates JH, Habashi NM. “Unshrinking the Baby Lung to Calm the VILI Vortex.” Crit Care. Aug 2022. 26(1):242. [PMID: 35934707]

 

31.      Ramcharran H, Satalin J, Blair S, Gaver DP, Gatto LA, Bates JHT, Wang G, Ghosh AJ, Robedee B, Vossler J, Habashi NM, Kollisch-Singule M, Nieman GF. “Protective Ventilation in a Pig Model of Acute Lung Injury: Timing is as Important as Pressure.” J Appl Physiol. Nov 2022. 133(5):1093-105. [PMID: 36135956]

 

32.      Ma J, Wang X, Gu R, Guo D, Shi C, Kollisch-Singule M, Suo L, Luo J, Meng Q, Cooney R. “Prophylactic nCMT-3 Attenuates Sepsis-Induced Acute Kidney Injury (AKI) by Blocking NLRP3 Inflammasome Activation and Apoptosis.” Shock. June 2023. 59(6):922-9. [PMID: 36939682

 

33.      Bates JHT, Nieman GF, Kollisch-Singule M, Gaver DP. “Ventilator-Induced Lung Injury as a Dynamic Balance Between Epithelial Cell Damage and Recovery.” ABME. Mar 2023. [PMID: 37000319]

 

34.      Bates JHT, Kaczka DW, Kollisch-Singule M, Nieman GF, Gaver DP. “Mechanical Power and Ventilator-Induced Lung Injury: What Does Physics Have to Say?” Am J Resp Crit Care Med. Sep 2023. [PMID: 37729623] Recognized by ATS Blue Journal as an Emerging Investigator.

 

35.      Nieman GF, Hermann J, Satalin J, Kollisch-Singule M, Andrews PL, Habashi NM, Tingay DG, Gaver DP, Bates JHT, Kaczka DW. “Ratchet Recruitment in the Acute Respiratory Distress Syndrome: Lessons Learned from the Newborn Cry.” Frontiers in Physiology. November 2023. 1-6. [PMID: 28028774]

 

36.      Cruz AF, Herrmann J, Ramcharran H, Kollisch-Singule M, Tawhai M, Bates JHT, Nieman GF, Kaczka DW. “Sustained vs. Intratidal Recruitment in the Injured Lung During Airway Pressure Release Ventilation: A Computational Modeling Perspective.” Mil Med. Dec 2023. 18; S6:141-8. [PMID: 37948236]

 

37.      Al-Khalisy H, Nieman GF, Kollisch-Singule M, Andrews PL, Camporata L, Shiber J, Manougian T, Satalin J, Blair S, Ghosh A, Herrmann J, Kaczka DW, Gaver DP, Bates JHT, Habashi NM. “Time-Controlled Adaptive Ventilation (TCAV): a personalized strategy for lung protection.” Respir Res. Jan 2024. 18;25(1):37. [PMID: 38238778]

 

38.      Ramcharran H, Wetmore G, Cooper S, Herrmann J, Cruz AF, Kaczka DW, Satalin J, Blair S, Andrews PL, Habashi NM, Nieman GF, Kollisch-Singule M. “Effects of Lung Injury and Abdominal Insufflation on Respiratory Mechanics and Lung Volume During Time-Controlled Adaptive Ventilation”. Resp Care. Feb 2024. [PMID: 38408775]

 

39.      Du C, Fikhman DA, Obeng EE, Dong JS, Leavitt ET, Saldanha LV, Hall M, Satalin J, Kollisch-Singule M, Monroe MBB. “Vanillic Acid-based Pro-coagulant Hemostatic Shape Memory Polymer Foams with Antimicrobial Properties against Drug-resistant Bacteria.” Acta Biomaterialia. Nov 2024. 189:254-269. PMID: 39343289.

 

40.      Bates JHT, Kaczka DW, Kollisch-Singule M, Nieman GF, Gaver DP. “Atelectrauma can be avoided if expiration is sufficiently brief: evidence from inverse modeling and oscillometry during airway pressure release ventilation.” Crit Care. Oct 2024. 28:329. PMID: 39380082.

 

41. Ramcharran H, Ghosh A, Meng Q, Li G, Chernov ES, Lutz M, Mansour HM, Satalin J, Satalin S, Gaver DP, Bates JHT, Nieman GF, Kollisch-Singule M. “Meconium Influences Pulmonary Short-Chain Fatty Acid Concentration in Porcine Meconium Aspiration Model.” Biomedicine Hub. Dec 2024. Accepted.

©2020 by Mikki Kollisch.

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